1/18/2023 0 Comments Srdx seikoPlant roots can sense and respond to a wide diversity of mechanical stimuli, including touch and gravity. The Rice E3-Ubiquitin Ligase HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENE 1 Modulates the Expression of ROOT MEANDER CURLING, a Gene Involved in Root Mechanosensing, through the Interaction with Two ETHYLENE- RESPONSE FACTOR Transcription Factors 1 The results provide new insights into mechanisms underlying DNA damage responses in fungi, including F. This study identified sixteen genes involved in the DNA damage response and is the first to characterise the novel transcription factor gene FHS 1, which is involved in the DNA damage response. Our genetic evidence demonstrated that the FHS 1-associated signalling pathway for DNA damage response is independent of the ATM or ATR pathways. Moreover, deletion of FHS 1 resulted in defects in perithecia production and virulence and led to the accumulation of DNA damage. fhs 1 deletion mutants were hypersensitive to hydroxyurea and defective in mitotic cell division. Fhs 1 is a fungal specific Zn(II)2Cys6 TF that localises exclusively to nuclei. Sixteen TFs were identified to be likely involved in DNA damage responses. To identify transcription factors (TFs) related to these processes, four DNA-damaging agents were applied to screen a F. Son, Hokyoung Fu, Minmin Lee, Yoonji Lim, Jae Yun Min, Kyunghun Kim, Jin-Cheol Choi, Gyung Ja Lee, Yin-WonĬell cycle regulation and the maintenance of genome integrity are crucial for the development and virulence of the pathogenic plant fungus Fusarium graminearum. All rights reserved.Ī novel transcription factor gene FHS 1 is involved in the DNA damage response in Fusarium graminearum However, results obtained in vitro may not easily be transferred to in vivo systems. The activation of stimulus- responsive transcription factors may explain many of the intracellular activities of resveratrol. The gene products of these delayed response genes are ultimately responsible for the changes in the biochemistry and physiology of resveratrol-treated cells. Following activation, these transcription factors induce transcription of delayed response genes. Here, we review the effect of resveratrol on the activation of the stimulus- responsive transcription factors CREB, AP- 1, Egr- 1, Elk- 1, and Nrf2. Resveratrol induces intracellular signal transduction pathways which ultimately lead to changes in the gene expression pattern of the cells. To explain the pleiotropic effects of resveratrol, the molecular targets of this compound have to be identified on the cellular level. Many health-promoting benefits have been connected with resveratrol in the treatment of cardiovascular diseases, cancer, diabetes, inflammation, neurodegeneration, and diseases connected with aging. Resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenolic phytoalexin of grapes and other fruits and plants, is a common constituent of our diet and of dietary supplements. Resveratrol regulates gene transcription via activation of stimulus- responsive transcription factors.
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